Join Insider Club FREE

I Want In! Already a member? Login

Connective Tissue Disorder

Connective Tissue Disorder

$257.00 - Free Shipping

The Connective Tissue Disorders panel tests for signs of a connective tissue disorder and provides a disease risk assessment.

Who should take this test?

If you suffer from any of these symptoms, this test may be right for you.

Hair loss
Muscle pain
Numbness/tingling in the hands/feet
Inflammation/damage to organs/tissues
Low-grade fever
Persistent fatigue/weakness
Arthritis-like pain in joints
Red rash
Skin sensitivity to light


Connective Tissue Disorder Blood Test

The Connective Tissue Disorders panel tests for signs of a connective tissue disorder and provides a disease risk assessment. Connective tissue disorders (CTD) are a group of medical diseases where the connective tissues of the body are attacked. Most CTDs feature abnormal immune system activity with autoimmune-induced inflammation, where the body attacks its own connective tissues. If you are diagnosed with or suspect chronic inflammation, autoimmune disease, or a wheat-related disorder, you may benefit from this panel.

Why is This Test Important?

  • Connective tissue disorder is highly inflammatory and tends to occur alongside other autoimmune disorders, including Raynaud’s Phenomenon, Neuropathy, Anemia, and Pleurisy or Pleuritis.
  • More than two million Americans suffer from the CTD rheumatoid arthritis.
  • Symptoms of CTD are difficult to diagnose. On average, people suffer with CTD symptoms for over three years before diagnosis.
  • The Vibrant Wellness Connective Tissue Disorders test provides the most comprehensive view of CTD is a single test run.
  • The panel allows you to predict, detect, monitor, and manage CTD, helping you and your provider optimize a therapeutic outcome.

Markers Measured

Connective Tissue Disorder Test markers measured:

Anti-nuclear Antibodies

ENA Profle-10

  • Jo-1
  • Sm
  • RNP
  • SSA (Ro)
  • SSB (La)
  • Scl-70
  • Chromatin
  • Centromere
  • Histone
  • RNA polymerase III

Rheumatoid Arthritis Associated markers

  • RF IgM
  • Anti-CCP3 IgG
  • Anti-CCP3 IgA


  •  Anti ds-DNA


Connective Tissue Disorder Symptoms

  • Hair loss
  • Muscle pain
  • Numbness or tingling in the hands or feet (Raynaud’s syndrome)
  • Inflammation and damage to organs and tissues including the kidney, lungs, heart, lining of the heart, central nervous system, and blood vessels
  • Low-grade fever
  • Persistent fatigue and weakness
  • Arthritis-like pain in one or more joints
  • Red rash (for lupus, one resembling a butterfly across the nose and cheeks)
  • Skin sensitivity to light

About Test

About Connective Tissue Disorder Test

Key Details

  • Sample collection must be performed by a phlebotomist any day Monday-Friday.
    • More information on scheduling a blood draw can be found HERE.
    • You may need to pay an additional fee for phlebotomy.
  • Review your kit - When you receive the test kit in the mail, review its contents, and read through the information provided with the kit.
  • Place frozen ice packs (if included with the kit) in the freezer for at least 24 hours prior to your appointment.
  • Scheduling your blood draw any day Monday-Friday.
    • Search for a "mobile phlebotomist" who will come to your home, or:
    • Locate a blood draw site HERE. Please note: Quest and LabCorp only draw for their own tests, not for Vibrant America tests.
    • If you are in a rural location, consider asking your doctor's office to draw for the kit, or, call your local hospital and ask if they offer this service.
    • You may need to pay an additional fee for phlebotomy.
    • Your test kit may come with more tubes than needed. Please have the phlebotomist check the collection instructions and your test requisition form to determine the correct tubes to draw. Your phlebotomist will know what to do with the tubes and instructions provided.
  • After the blood draw is collected, you are all done! Your phlebotomist will process, package and ship your completed kit for you.

What to bring to your appointment:

  • Frozen ice packs
  • Full test kit with all contents and forms
  • Fasting is not required for your kit. Drink plenty of water.

Verify the kit contents, which typically includes:

  • Requisition form: lab orders needed for the phlebotomist to draw your samples. Confirm your information is correct on this form.
    • Since your kit has been prepaid, you do not need to fill in the payment information on any of these forms.
  • Tubes: these are specific to the samples the test requires and some may have extra reagents in the tubes (this is not condensation!)
  • Ice pack: if present, place in the freezer (you must bring these to the phlebotomy appointment)
  • Shipping materials: a biohazard bag for your samples & return shipping label
  • For return shipment tracking, take a picture of the shipping label if you'd like to track status of the kit; most labs can't provide this information once the kit is shipped
  • Draw instructions: for the phlebotomist to confirm the test specific instructions.

Preparation & Timing

  • Sample collection must be performed Monday-Friday only by a phlebotomist.
    • More information on scheduling a blood draw can be found HERE.
    • You can find a Vibrant America-partnered blood draw location HERE.
  • If you are currently taking (or have recently taken) any of the following medications, consult your healthcare provider regarding the timing of collection.
    • Steroids
    • Immunosuppressive medications
    • Biologic agents
    • Other immunomodulating medications
  • Hydrate the day prior to the test.
  • Freeze the provided ice packs for at least 24 hours prior to your blood draw.

Requisition & Payment

  • Your kit has been prepaid. You may need to pay an additional fee for phlebotomy.
  • Instructions on how to fill out your requisition can be found HERE.
    • Since you pre-paid for your tests, you do not need to fill in the payment information on any of these forms.

The Vibrant Experience

Vibrant America is a leading science and technology company delivering life-transforming laboratory services using an integrated microarray platform that enables multiplex testing at an affordable cost.

Vibrant’s relationship with its patients and providers is special. We go out of our way to provide the value and resources our providers need to accurately interpret test results and give patients the most accurate health information.

The Most Accurate In the Industry

All tests run on Vibrant’s proprietary 3Dense microchip technology platform boast an unrivaled specificity and sensitivity – which translates to the highest standard of accuracy of results in the lab industry.

Our Lab Technology

Vibrant America is at the forefront of modern medicine. Our technology was developed out of passion for better medicine, and we believe that automation is the key to high-quality and accurate test results. Multiplexing tests on a single sample enable a fast turnaround time.

Our Mission

Dedicated to bring clinically relevant test at a rapid pace to enable affordable high-quality diagnostics to every individual.

  • High-quality lab service
  • Fully automated systems
  • Low cost
  • Fast Turn Around Time

Quality and Security

All of our laboratory testings is done in a CLIA and CAP-certified laboratory in California.

Vibrant America's Compliance Overview



Should I discontinue my supplements when I take this test?

We recommend you stay off supplements for a week before you take this test.

Where is the testing performed?

All testings are performed at Vibrant America Clinical Labs at San Carlos.

Should I fast before the blood is drawn?

Not necessary to fast before blood draw.

How It Works


Order your test

You'll get an email confirmation from us.


Within 48 hours of payment

The lab will confirm your order and provide tracking.


2 days after kits ship

We will send you test instructions.


When results are in

You'll be notified via email, with instructions to access via secured portal.



Learn how to read your lab report.

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

*Regulatory Statement*
Vibrant testing does not demonstrate absolute positive and negative predictive values for any disease state or condition. Its clinical utility has not been fully established. Vibrant validates the accuracy and precision of the testing but not of its clinical or diagnostic value. So these tests are for wellness and informational purpose only. Vibrant is actively doing clinical research on these samples, de-identified from patients under an IRB and will make research publications towards the same as and when the clinical utility is well established. These tests have been laboratory developed and their performance characteristics determined by Vibrant America LLC, a CLIA-certified laboratory performing the test CLIA#:05D2078809. The test has not been cleared or approved by the U.S. Food and Drug Administration (FDA). Although FDA does not currently clear or approve laboratory-developed tests in the U.S., certification of the laboratory is required under CLIA to ensure the quality and validity of the tests. The general wellness test intended uses relate to sustaining or offering general improvement to functions associated with a general state of health while making reference to diseases or conditions. Content provided for informational purposes only and should not be construed as medical advice. Content provided to help you make a healthy lifestyle, dietary, and treatment choices in consultation with your healthcare provider. It is intended to be used as a tool to encourage a general state of health and well-being. Please consult with your healthcare practitioner for diagnosis and treatment considerations. The Vibrant Wellness platform provides tools for you to track and analyze your general wellness profile.